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https://idr.l2.nitk.ac.in/jspui/handle/123456789/13278
Title: | Synthesis of some new pyrazolone derivatives as potent antimicrobial agents |
Authors: | Vijesh, A.M. Isloor, A.M. Isloor, S. Shivananda, K.N. Shyma, P.C. Arulmoli, T. |
Issue Date: | 2011 |
Citation: | Der Pharma Chemica, 2011, Vol.3, 4, pp.454-463 |
Abstract: | Invasive microbial infections are major problems around the world, especially in immuno compromised patients. The recent expansion of antimicrobial drug research has occurred because there is a critical need for new antimicrobial agents to treat these life threatening invasive infections. In the present study three series of new substituted pyrazolone derivatives (5a-f, 6a-f and 8a,b) were synthesized by the Knoevenagel condensation reaction of pyrazolones (3a,b) with various substituted carbaldehydes (4a-f, 7). These newly synthesized compounds were characterized by IR, NMR, mass spectra and also by C, H, N analyses. New compounds were screened for their antimicrobial studies against S. aureus, B. subtilis, E. coli and P. aeruginosa. The results revealed that compounds 5c and 6c having 2,5-dichlorothiophene substituent showed significant antibacterial activity against all tested microorganisms as compared to the standard drug Ceftriaxone. |
URI: | http://idr.nitk.ac.in/jspui/handle/123456789/13278 |
Appears in Collections: | 1. Journal Articles |
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