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Title: | Novel chromeno [2,3-b]-pyrimidine derivatives as potential anti-microbial agents |
Authors: | Sankappa, Rai, U. Isloor, A.M. shetty, P. Vijesh, A.M. Prabhu, N. Isloor, S. Thiageeswaran, M. Fun, H.-K. |
Issue Date: | 2010 |
Citation: | European Journal of Medicinal Chemistry, 2010, Vol.45, 6, pp.2695-2699 |
Abstract: | An efficient, microwave irradiated synthesis of novel chromeno[2,3-b]-pyrimidine derivatives was carried out. 2-Amino-3,4-dihydro-2H-chromene-3-carbonitrile was converted into imine using N,N-Dimethylacetaldehyde dimethylacetal to give the core intermediate, which was used for the preparation of chromenopyrimidine library, using acetic acid and different amine in microwave irradiation for 5 min. Structures of newly synthesized compounds were confirmed by spectral studies. Compound 6g was characterized by single crystal X-ray analysis. All the compounds were also screened for their anti-microbial activity. Few of the compounds are found to be potential antimicrobials. 2010 Elsevier Masson SAS. All rights reserved. |
URI: | http://idr.nitk.ac.in/jspui/handle/123456789/12285 |
Appears in Collections: | 1. Journal Articles |
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