Please use this identifier to cite or link to this item: https://idr.l2.nitk.ac.in/jspui/handle/123456789/13314
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dc.contributor.authorSathish, N.K.-
dc.contributor.authorGopKumar, P.-
dc.contributor.authorRajendra, Prasad, V.V.S.-
dc.contributor.authorShanta, Kumar, S.M.-
dc.contributor.authorMayur, Y.C.-
dc.date.accessioned2020-03-31T08:45:35Z-
dc.date.available2020-03-31T08:45:35Z-
dc.date.issued2010-
dc.identifier.citationMedicinal Chemistry Research, 2010, Vol.19, 7, pp.674-689en_US
dc.identifier.urihttp://idr.nitk.ac.in/jspui/handle/123456789/13314-
dc.description.abstractA series of new 1,3-dimethyl acridone derivatives were synthesized with different alkyl side chain (propyl and butyl) substitution at N 10-position and highly basic amine groups at terminal end of alkyl side chain. All the synthesized molecules were screened for their cytotoxic activity against human breast adenocarcinoma (MCF-7) and human promyelocytic leukemia (HL-60) cell lines. DNA binding constants (Ki) of selected compounds were determined with calf-thymus DNA. Results showed that the molecules 7, 8, 10, 11, 12, 13, 14, and 15 exhibited good cytotoxic activity with IC50 value <10 ?M. Compound 14 having (?- hydroxyethyl) piperazine butyl side chain exhibited potent cytotoxic activity against MCF-7 cell line and DNA-intercalating properties. Examination of the relationship between lipophilicity and acridone derivatives showed poor correlation. Birkh user Boston 2009.en_US
dc.titleSynthesis, chemical characterization of novel 1,3-dimethyl acridones as cytotoxic agents, and their DNA-binding studiesen_US
dc.typeArticleen_US
Appears in Collections:1. Journal Articles

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