Please use this identifier to cite or link to this item: https://idr.l2.nitk.ac.in/jspui/handle/123456789/13280
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dc.contributor.authorWagle, S.-
dc.contributor.authorAdhikari, A.V.-
dc.contributor.authorKumari, N.S.-
dc.date.accessioned2020-03-31T08:45:31Z-
dc.date.available2020-03-31T08:45:31Z-
dc.date.issued2008-
dc.identifier.citationPhosphorus, Sulfur and Silicon and the Related Elements, 2008, Vol.183, 5, pp.1285-1300en_US
dc.identifier.urihttp://idr.nitk.ac.in/jspui/handle/123456789/13280-
dc.description.abstractA series of 4-aryl-2-(3-methyl-7-substituted quinoxaline-2-one-1-yl)-1,3- thiazoles (6a-l) and 4-substituted alkyl-2-(3-methyl-7-substituted quinoxaline-2-one-1-yl)-1,3-thiazoles (8a-i) were synthesized in good yield by condensing 2-(3-methyl-7-substituted l,2-oxoquinoxalin-1(2H)-yl)ethanethioamides (5a-c) with substituted phenacyl bromide and dichloroacetone followed by treatment with secondary amines, respectively. The intermediates, 5a-c were conveniently obtained by reacting phosphorus pentasulphide with 2-(3-methyl-7-substituted-2-oxoquinoxalin-1(2H)-yl) acetamides (4a-c) which in turn were synthesized from ethyl (3-methyl-7-substituted-2-oxoquinoxalin-1(2H)- yl) acetates (3a-c) by aqueous ammonia treatment. The newly synthesized compounds were characterized by IR, 1H NMR, 13C NMR, and Mass spectral and elemental analyses. These compounds were screened for in vitro antibacterial activity against five pathogenic strains and antifungal activity against four fungi. Preliminary results revealed that some of the synthesized compounds showed promising antimicrobial activity. Copyright Taylor & Francis Group, LLC.en_US
dc.titleSynthesis of some novel 2,4-disubstituted thiazoles as possible antimicrobial agentsen_US
dc.typeArticleen_US
Appears in Collections:1. Journal Articles

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