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dc.contributor.authorKarabasanagouda, T.-
dc.contributor.authorAdhikari, A.V.-
dc.contributor.authorParameshwarappa, G.-
dc.date.accessioned2020-03-31T08:45:30Z-
dc.date.available2020-03-31T08:45:30Z-
dc.date.issued2009-
dc.identifier.citationJournal of the Serbian Chemical Society, 2009, Vol.74, 7, pp.733-743en_US
dc.identifier.urihttp://idr.nitk.ac.in/jspui/handle/123456789/13273-
dc.description.abstractA series of new 4-aryl-2'-[(4-hydroxyphenyl)thio]-6oxo-1,6-dihydro-2,4'-bipyridine-5-car bonitriles (3a-k) and 6-amino-4aryl-2'-[(4-hydroxyphenyl) thio]-2,4'-bipyridine-5-carbonitriles (4a-h) were synthesized from 4-hydroxythiophenol (1). The reaction of 4-hydroxythiophenol with 4-acetyl-2-chloropyridine yielded 1-{2-[(4-hydroxyphenyl)thio]pyridin-4-yl}ethanone (2). Further treatment of 2 with ethyl cyanoacetate in the presence of ammonium acetate with various aromatic aldehydes furnished the compounds 3a-k. On the other hand, condensation of 2 with aromatic aldehydes in the presence of alcoholic malononitrile in ammonium acetate gave compounds 4a-h. The structures of the newly synthesized compounds were established on the basis of their elemental analysis, as well as their IR, 1H- and 13C-NMR and mass spectral data. All the title compounds were subjected to in vitro antibacterial testing against two strains and antifungal screening against two fungi. Some of the compounds showed promising activity. 2009 Copyright (CC) SCS.en_US
dc.titleSynthesis of some biologically active 2,4'-bipyridine-5-carbonitriles carrying the 4-hydroxyphenylthio moiety [Russian Source]en_US
dc.typeArticleen_US
Appears in Collections:1. Journal Articles

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