Please use this identifier to cite or link to this item: https://idr.l2.nitk.ac.in/jspui/handle/123456789/13196
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dc.contributor.authorMalladi, S.-
dc.contributor.authorIsloor, A.M.-
dc.contributor.authorShetty, P.-
dc.contributor.authorFun, H.K.-
dc.contributor.authorTelkar, S.-
dc.contributor.authorMahmood, R.-
dc.contributor.authorIsloor, N.-
dc.date.accessioned2020-03-31T08:45:22Z-
dc.date.available2020-03-31T08:45:22Z-
dc.date.issued2012-
dc.identifier.citationMedicinal Chemistry Research, 2012, Vol.21, 10, pp.3272-3280en_US
dc.identifier.urihttp://idr.nitk.ac.in/jspui/handle/123456789/13196-
dc.description.abstractIn the present study, a new series of 3,6-disubstituted- 1,2,4-triazolo-[3,4-b]-1,3,4-thiadiazoles (4aj) have been synthesized by condensing 3-substituted-4-amino-5- mercapto-1,2,4-triazoles (1a-b) with various 3-substitutedpyrazole- 4-carboxylic acids (3a-e) in the presence ofPOCl3. The structures of newly synthesized compounds were characterized by elemental analysis, IR, 1H NMR, 13CNMR, and mass spectroscopic studies. Structure of the compound 4b was also confirmed by recording the single crystal X-ray structure. All the synthesized compounds were screened for their anti-inflammatory activities by carrageenan induced paw edema method. Anti-inflammatory screening indicated that, compounds 4d, 4e, and 4h were found to be biologically active whereas remaining compounds showed poor antiinflammatory activity. Also molecular docking studies were also performed for compounds which showed good antiinflammatory activity. Springer Science+Business Media, LLC 2011.en_US
dc.titleSynthesis and anti-inflammatory evaluation of some new 3,6-disubstituted-1, 2,4-triazolo-[3,4-b]-1,3,4-thiadiazoles bearing pyrazole moietyen_US
dc.typeArticleen_US
Appears in Collections:1. Journal Articles

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